molecular chaperones or amyloid-binding compounds? perspective on their application as possible therapeutic agents in reduction of cytotoxicity of amyloid oligomers
نویسندگان
چکیده
molecular chaperones or amyloid-binding compounds? perspective on their application as possible therapeutic agents in reduction of cytotoxicity of amyloid oligomers
منابع مشابه
Amyloid-/? oligomers: their production, toxicity and therapeutic inhibition
Despite extensive genetic and animal modelling data that support a central role for the amyloid /?-protein (Am in the genesis of Alzheimer's disease, the specific form(s) of A/? which causes injury to neurons in vivo has not been identified. In the present study, we examine the importance of soluble, pre-fibrillar assemblies of A/? as mediators of neurotoxicity. Specifically, we review the role...
متن کاملMolecular mechanisms of amyloid oligomers toxicity.
Amyloid oligomers have emerged as the most toxic species of amyloid-β (Aβ). This hypothesis might explain the lack of correlation between amyloid plaques and memory impairment or cellular dysfunction. However, despite the numerous published research articles supporting the critical role Aβ oligomers in synaptic dysfunction and cell death, the exact definition and mechanism of amyloid oligomers ...
متن کاملsynthesis of 3-aryl-2h-benzo[b]-1,4-oxazines in [omim]bf4 and reduction of organic compounds in methylimidazolium formate
در این پروژه ترکیبات 3-آریل-2h-بنزو[b]-4،1-اکسازین ها از مواد اولیه تجاری مشتقات دو آمینو فنول و ?-هالو کتون های آروماتیک در مایع یونی 1-اکتیل-3-متیل ایمیدازولیوم تترا فلورو بورات([omim]bf4) سنتز شده است. این واکنش توسط باز پتاسیم کربنات محلول از طریق o-آلکیلاسیون و سپس یک واکنش آمیداسیون درون مولکولی خود بخود در مدت زمان کوتاه انجام می شود. ترکیبات 4،1-بنزوکسازین به این روش با بهره خوب تا آلی ...
15 صفحه اولdetection of volatile compounds of medicinal plants with some nano-sorbents using modified or new methodologies and investigation of antioxidant activity of their methanolic extracts
in this work, a novel and fast method for direct analysis of volatile compounds (davc) of medicinal plants has been developed by holding a filament from different parts of a plant in the gc injection port. the extraction and analysis of volatile components of a small amount of plant were carried out in one-step without any sample preparation. after optimization of temperature, extraction time a...
Possible Function of Molecular Chaperones in Diseases Caused by Propagating Amyloid Aggregates
The vast majority of neurodegenerative pathologies stem from the formation of toxic oligomers and aggregates composed of wrongly folded proteins. These protein complexes can be released from pathogenic cells and enthralled by other cells, causing the formation of new aggregates in a prion-like manner. By this mechanism, migrating complexes can transmit a disorder to distant regions of the brain...
متن کاملSalvianic borneol ester reduces β-amyloid oligomers and prevents cytotoxicity.
CONTEXT The destabilization of β-amyloid (Aβ) peptide aggregates and the protection of functional cells are the attractive therapeutic strategies for Alzheimer's disease (AD). Some active ingredients of Salvia miltiorrhiza f. alba C.Y.Wu & H.W.Li (Lamiaceae) (SM) have attracted increasing attention for the treatment of neurodegenerative diseases. OBJECTIVE Salvianic borneol ester (SBE) is a n...
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عنوان ژورنال:
journal of reports in pharmaceutical sciencesجلد ۲، شماره ۲، صفحات ۲۰۵-۲۰۶
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